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Ce que nous avons appris du COVID-19 : des morts qui auraient pu être évités? — Pr Philippe Parola | IHU Méditerranée-Infection

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IHU Méditerranée-Infection

L’IHU Méditerranée Infection face à la crise du COVID-19 Témoignage du Pr Philippe Parola, directeur de service de soins et d’unité de recherche à l’IHU Méditerranée Infection

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Link to a dynamic archive of studies on the use of HCQ(-AZ) as a prophylaxis for COVID-19: COVID-19 studies for: HCQ, Ivermectin, Vitamin D, Zinc, REGN-COV2, LY-CoV, Remdesivir

Related Study:

Published online 2020 Jun 25.

Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis

Abstract

Background

In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization and early treatment with hydroxychloroquine and azithromycin (HCQ-AZ) was proposed for the positive cases.

Methods

We retrospectively report the clinical management of 3,737 screened patients, including 3,119 (83.5%) treated with HCQ-AZ (200 mg of oral HCQ, three times daily for ten days and 500 mg of oral AZ on day 1 followed by 250 mg daily for the next four days, respectively) for at least three days and 618 (16.5%) patients treated with other regimen (“others”). Outcomes were death, transfer to the intensive care unit (ICU), ≥10 days of hospitalization and viral shedding.

Results

The patients’ mean age was 45 (sd 17) years, 45% were male, and the case fatality rate was 0.9%. We performed 2,065 low-dose computed tomography (CT) scans highlighting lung lesions in 592 of the 991 (59.7%) patients with minimal clinical symptoms (NEWS score = 0). A discrepancy between spontaneous dyspnoea, hypoxemia and lung lesions was observed. Clinical factors (age, comorbidities, NEWS-2 score), biological factors (lymphocytopenia; eosinopenia; decrease in blood zinc; and increase in D-dimers, lactate dehydrogenase, creatinine phosphokinase, troponin and C-reactive protein) and moderate and severe lesions detected in low-dose CT scans were associated with poor clinical outcome. Treatment with HCQ-AZ was associated with a decreased risk of transfer to ICU or death (Hazard ratio (HR) 0.18 0.11–0.27), decreased risk of hospitalization ≥10 days (odds ratios 95% CI 0.38 0.27–0.54) and shorter duration of viral shedding (time to negative PCR: HR 1.29 1.17–1.42). QTc prolongation (>60 ms) was observed in 25 patients (0.67%) leading to the cessation of treatment in 12 cases including 3 cases with QTc> 500 ms. No cases of torsade de pointe or sudden death were observed.

Conclusion

Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments.

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Will there be a boom? — Adam Booth | Fightback: The Marxist Voice of Labour and Youth

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Source: Fightback: The Marxist Voice of Labour and Youth

Will there be a boom?

ADAM BOOTH ★ NOV 19, 2020

Source: Pixabay

The world is breathing a collective sigh of relief at news that a viable vaccine may be in sight. With this comes the prospect of an end to the pandemic and a return to normality.

Ordinary people are no doubt looking forward to going out again, and being able to spend time with friends and family.

But it is the capitalists who are particularly jubilant – euphoric at the thought of lining their pockets as the economy restarts and the profit-making resumes (not that it ever really stopped).

This elation has been reflected in record highs on the stock market, with investors toasting the simultaneous news of a Biden victory and a potential breakthrough in the search for a COVID-19 cure.

These celebrations may prove to be premature, however. Hopes of a rapid recovery are misplaced. After suffering such a devastating blow from the virus, the global capitalist economy will not rebound, but will be scarred for life.

Even before COVID hit, the capitalist system was in a state of senile decay. The pandemic certainly exacerbated and accelerated this decline. But capitalism’s crisis did not begin with coronavirus. And they will not end with it either.

The reality is that there will be no return to ‘normality’. There will be no real recovery — especially not for the working class and the poor.

The perspective ahead is not one of boom. Rather, we will see a ‘new normal’ – one of crises, austerity and attacks. We are entering a new epoch, in which the class struggle will be intensified, and the question of revolution will be on the order of the day.

All that is solid

The year 2020 will forever be defined by the coronavirus crisis. The world has been turned upside down and inside by the pandemic. In the words of the Communist Manifesto: all that was solid has melted into air – “and man is at last compelled to face with sober senses his real conditions of life, and his relations with his kind.”

The market system has gone into a tailspin. Even with a total of almost $12 trillion in state support worldwide (equivalent to 12% of global output), GDP has plummeted.

Stocks Image Quoteinspector
Source: Quoteinspector

In their latest ‘World Economic Outlook’ report, the IMF predicts that global output will fall by 4.4% this year – the worst downturn since the Great Depression of the 1930s. This figure is 5.8% for the advanced economies, and a fall of more than 10% is predicted for countries such as Britain, France, Italy, and Spain, and that was before the latest wave of the virus became apparent.

In order to curb the spread of the virus, lockdowns and restrictions of some kind have been in place in almost all the major capitalist countries since March. Faced with these measures, society was forced to adapt. Most people have experienced dramatic changes in terms of their daily lives.

Almost overnight, millions shifted to working from home. Tumbleweed now blows down high streets and in shopping malls, with retail moving online. And cinemas and stadiums have closed their doors, as viewers watch movies and sports matches from their sofas.

For workers in affected industries – such as hospitality, entertainment, and tourism – the impact has been severe. But even then, much of the blow has been softened by government furlough schemes, which have acted to prop up jobs and keep the economy in a state of suspended animation.

Even with the capitalist system as a whole mired in crisis, a section of the capitalists are laughing all the way to the bank. According to one recent Oxfam report, the 100 most valuable companies globally have added $3 trillion of stock market value in total this year. Shares for Apple, Microsoft, Facebook, Google, and Amazon in particular have soared.

As a result, these same giant tech firms are predicted to make an additional $46 billion in profits thanks to the pandemic. Already the world’s richest person, Amazon boss Jeff Bezos has seen his personal fortune increase by $94 billion.

All of these changes brought about by the virus will not be so easily reversed. Life has been irrevocably transformed. Even with a vaccine, things will never be the same again. Continue reading