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Source: Let’s Be Clear

What leads to more spike protein in the body: the vaccine or virus? Part 1

A reply to an article by Uri Manor and Jeremy Howard

By Joomi Kim

November 11, 2021


The SARS-CoV-2 virus has a protein on its surface called the spike protein. The COVID vaccines available in the U.S. work by getting the body to produce this protein (with some modifications). 

In a previous article, I went over multiple pieces of evidence showing that the spike protein alone, either from the virus or vaccine, is harmful.

A few people responded to that article by bringing up Uri Manor, an Assistant Research Professor at the Salk Institute, and senior co-author of a paper by Lei et al., which was one of the studies showing that spike protein was harmful. This paper was also one of the studies I linked to and briefly discussed in my previous article about the spike protein.

After the Lei et al. paper came out, some said that it was being used to spawn “anti-vax discussions”:

In Manor’s reply, he said that “the (relatively) small amount of spike protein produced by the mRNA vaccine would not be nearly enough to do any damage.”

Later on, Manor cited a study by Ogata et al., which actually measured the amount of free spike protein in the plasma of Moderna vaccine recipients:

Congrats to @OgataAlana on this important study. Many asked how much spike protein gets into circulation after vaccination. Turns out to average ~30-40 pg/mL for a few days then disappears.

FYI: This is ~100,000x less than used in our paper (4 ug/mL).


Originally tweeted by Uri Manor (@manorlaboratory) on May 21, 2021.

Manor said that the Ogata study showed that the amount of free spike was ~100,000 times less than the paper he was a co-author on (the one which showed harmful effects of the spike protein).

After that, he and Jeremy Howard produced this article:

SARS-CoV-2 spike protein impairment of endothelial function does not impact vaccine safety

In their article, Manor and Howard don’t seem to deny the possibility that the spike protein from vaccines is harmful, but argue that the amount of spike protein produced from them is physiologically negligible.

Side note: you may have heard of Jeremy Howard in the context of data science or machine learning. Yes, this is the same Jeremy Howard.

So let’s look at what the Ogata study shows and examine the claims made by Manor and Howard.

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